Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N1FS
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| Former ID |
DNC000544
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| Drug Name |
Diacerein
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| Synonyms |
Diacerein; 13739-02-1; Diacetylrhein; Diacerhein; Fisiodar; Artrodar; 1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE; DIACERIN; 4,5-Diacetylrhein; Diacereinum [Latin]; Diacereine [French]; Diacereina [Spanish]; UNII-4HU6J11EL5; Diacerein [INN]; SF-277; C19H12O8; EINECS 237-310-2; BRN 2184909; 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid; MLS000028577; 4HU6J11EL5; 1,8-Diacetoxyanthraquinone-3-carboxylic acid; Diacerein (INN); 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid; NCGC00018274-04; SMR000058958; AK468692
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C19H12O8
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| Canonical SMILES |
CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C2=O)C=C(C=C3OC(=O)C)C(=O)O
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| InChI |
1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
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| InChIKey |
TYNLGDBUJLVSMA-UHFFFAOYSA-N
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| CAS Number |
CAS 13739-02-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855680, 4363810, 8169045, 11341914, 11362097, 11364807, 11367369, 11369931, 11372073, 11374729, 11378098, 11484481, 11487499, 11488639, 11490752, 11492850, 11495690, 12012675, 14901773, 24894281, 26612251, 26680442, 26746957, 28325764, 29293111, 47942826, 49830871, 49870698, 50100992, 51091608, 57310202, 76715691, 80030301, 81041119, 85279713, 91011503, 103220500, 104171387, 104296775, 117575544, 117689433, 124638102, 124883601, 124883602, 125325747, 125340536, 126592381, 126666939, 129332407, 131298280
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| ChEBI ID |
CHEBI:94708
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| SuperDrug ATC ID |
M01AX21
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| SuperDrug CAS ID |
cas=013739021
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Diacerein (adjusted p-values: 7.65E-06). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Diacerein (adjusted p-values: 7.62E-06). | |||
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Studied Microbe: Bacteroides ovatus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Diacerein (adjusted p-values: 1.51E-05). | |||
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Studied Microbe: Bacteroides uniformis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Diacerein (adjusted p-values: 6.54E-07). | |||
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Studied Microbe: Bacteroides vulgatus
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Diacerein (adjusted p-values: 2.39E-06). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Diacerein (adjusted p-values: 8.17E-06). | |||
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Studied Microbe: Odoribacter splanchnicus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides distasonis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Diacerein (adjusted p-values: 1.94E-05). | |||
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Studied Microbe: Parabacteroides merdae
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Diacerein (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Prevotella copri
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Diacerein (adjusted p-values: 8.04E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Diacerein (adjusted p-values: 4.93E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Diacerein (adjusted p-values: 1.68E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Diacerein (adjusted p-values: 5.84E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Diacerein (adjusted p-values: 7.48E-07). | |||
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Studied Microbe: Clostridioides difficile
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Diacerein (adjusted p-values: 5.37E-06). | |||
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Studied Microbe: Clostridium perfringens
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Diacerein (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Coprococcus comes
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Dorea formicigenerans
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Enterocloster bolteae
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Eubacterium eligens
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Diacerein (adjusted p-values: 2.08E-05). | |||
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Studied Microbe: Eubacterium rectale
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Diacerein (adjusted p-values: 1.71E-04). | |||
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Studied Microbe: Lacrimispora saccharolytica
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Diacerein (adjusted p-values: 4.78E-07). | |||
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Studied Microbe: Roseburia hominis
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Diacerein (adjusted p-values: 1.69E-05). | |||
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Studied Microbe: Roseburia intestinalis
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Diacerein (adjusted p-values: 2.03E-04). | |||
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Studied Microbe: Ruminococcus bromii
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Ruminococcus gnavus
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Diacerein (adjusted p-values: 6.24E-06). | |||
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Studied Microbe: Ruminococcus torques
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Diacerein (adjusted p-values: 7.81E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Streptococcus parasanguinis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Diacerein (adjusted p-values: 6.82E-06). | |||
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Studied Microbe: Streptococcus salivarius
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Diacerein (adjusted p-values: 6.72E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
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Studied Microbe: Veillonella parvula
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Diacerein (adjusted p-values: 5.04E-06). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 2 | Non-surgical treatment of osteoarthritis of large joints - new aspects. Wien Med Wochenschr. 2009;159(3-4):76-86. | |||
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