Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N1BF
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| Former ID |
DIB008739
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| Drug Name |
LY-2811376
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| Synonyms |
LY2811376; 1194044-20-6; (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; LY-2811376; LY 2811376; UNII-UR18YJ97SJ; UR18YJ97SJ; CHEMBL2333941; (4s)-4-[2,4-Difluoro-5-(Pyrimidin-5-Yl)phenyl]-4-Methyl-5,6-Dihydro-4h-1,3-Thiazin-2-Amine; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine; J-501480; MJQMRGWYPNIERM-HNNXBMFYSA-N; 4H-1,3-Thiazin-2-amine, 4-(2,4-difluoro-5-(5-pyrimidinyl)phenyl)-5,6-dihydro-4-methyl-, (4S)-; 4H-1,3-Thiazin-2-amine,
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 1 | [1], [2] | |
| Company |
Eli Lilly & Co
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| Structure |
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Download2D MOL |
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| Formula |
C15H14F2N4S
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| Canonical SMILES |
CC1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F
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| InChI |
1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1
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| InChIKey |
MJQMRGWYPNIERM-HNNXBMFYSA-N
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| CAS Number |
CAS 1194044-20-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
85286240, 89983742, 99437206, 103924885, 137986191, 140419282, 144116165, 144236995, 160828708, 162011703, 162205125, 163093680, 163390266, 163620704, 163686021, 163842305, 164135005, 164193941, 172086121, 174006688, 174526511, 178103518, 184816523, 188899592, 204429761, 223378259, 223621253, 223705125, 224326043, 227634630, 242586937, 247529799, 249730473, 249807610, 249855753, 250200952, 251910650, 251963140, 252069907, 252109923, 252160837, 252444081, 252451578
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Beta-secretase (BACE) | Target Info | Inhibitor | [3], [4] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6936). | |||
| REF 2 | ClinicalTrials.gov (NCT00838084) A Safety Study of LY2811376 Single Doses in Healthy Subjects. U.S. National Institutes of Health. | |||
| REF 3 | Neurodegenerative disease: Inhibiting beta-secretase in humans. Nature Reviews Drug Discovery 11, 21 (January 2012). | |||
| REF 4 | Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. J Neurosci. 2011 Nov 16;31(46):16507-16. | |||
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