Drug Information
Drug General Information | Top | |||
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Drug ID |
D0MZ9A
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Former ID |
DIB012363
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Drug Name |
Suronacrine maleate
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Synonyms |
HP-128; Suronacrine maleate < Rec INNM; Rac-9-(Benzylamino)-1,2,3,4-tetrahydroacridin-1-ol maleate
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Drug Type |
Small molecular drug
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Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Phase 3 | [1] | |
Structure |
Download2D MOL |
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Formula |
C24H24N2O5
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Canonical SMILES |
C1CC(C2=C(C3=CC=CC=C3N=C2C1)NCC4=CC=CC=C4)O.C(=CC(=O)O)C(=O)O
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InChI |
1S/C20H20N2O.C4H4O4/c23-18-12-6-11-17-19(18)20(15-9-4-5-10-16(15)22-17)21-13-14-7-2-1-3-8-14;5-3(6)1-2-4(7)8/h1-5,7-10,18,23H,6,11-13H2,(H,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1-
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InChIKey |
JRQSVNSUJOFXHC-BTJKTKAUSA-N
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CAS Number |
CAS 113108-86-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Acetylcholinesterase (AChE) | Target Info | Modulator | [2] |
Norepinephrine transporter (NET) | Target Info | Modulator | [2] | |
KEGG Pathway | Glycerophospholipid metabolism | |||
Cholinergic synapse | ||||
Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
Nicotinic acetylcholine receptor signaling pathway | ||||
Pathwhiz Pathway | Phospholipid Biosynthesis | |||
Pathway Interaction Database | ATF-2 transcription factor network | |||
Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
WikiPathways | Monoamine Transport | |||
NRF2 pathway | ||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
Biogenic Amine Synthesis | ||||
Acetylcholine Synthesis | ||||
Integrated Pancreatic Cancer Pathway |
References | Top | |||
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REF 1 | Handbook of Dementing Illnesses, Morris John. Page(570). | |||
REF 2 | Potential clinical use of an adrenergic/cholinergic agent (HP 128) in the treatment of Alzheimer's disease. Ann N Y Acad Sci. 1991;640:263-7. |
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