Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0MY7X
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| Former ID |
DIB005524
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| Drug Name |
Esonarimod
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| Synonyms |
Sonatimod; KE-298; KE-749; KE-758; NE-298; (R)-KE-298; (S)-KE-298
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD-11: FA20] | Phase 3 | [1] | |
| Company |
Taisho Pharmaceutical Co Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H16O4S
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| Canonical SMILES |
CC1=CC=C(C=C1)C(=O)CC(CSC(=O)C)C(=O)O
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| InChI |
1S/C14H16O4S/c1-9-3-5-11(6-4-9)13(16)7-12(14(17)18)8-19-10(2)15/h3-6,12H,7-8H2,1-2H3,(H,17,18)
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| InChIKey |
YRSSFEUQNAXQMX-UHFFFAOYSA-N
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| CAS Number |
CAS 101973-77-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:31559
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TNF-alpha/IL-1 beta production (TNFA/IL1B produ) | Target Info | Modulator | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | KE-758, an active metabolite of the new anti-rheumatic drug KE-298, suppresses production of tumor necrosis factor-alpha and interleukin-1 beta in THP-1, a human monocyte cell line. Drugs Exp Clin Res. 2002;28(5):197-205. | |||
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