Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0MD8D
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| Drug Name |
Tecovirimat
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| Synonyms |
Tecovirimat; ST 246; SIGA-246; UNII-F925RR824R; 816458-31-8; F925RR824R; ST-246; TPOXX; Tecovirimat [USAN:INN]; SIGA 246
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| Indication | Smallpox [ICD-11: 1E70; ICD-10: B03] | Approved | [1] | |
| Virus infection [ICD-11: 1A24-1D9Z] | Phase 3 | [2] | ||
| Company |
SIGA Technologies
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| Structure |
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Download2D MOL |
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| Formula |
C19H15F3N2O3
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| Canonical SMILES |
C1C2C1C3C=CC2C4C3C(=O)N(C4=O)NC(=O)C5=CC=C(C=C5)C(F)(F)F
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| InChI |
1S/C19H15F3N2O3/c20-19(21,22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6,10-15H,7H2,(H,23,25)/t10-,11+,12+,13-,14-,15+
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| InChIKey |
CSKDFZIMJXRJGH-VWLPUNTISA-N
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| CAS Number |
CAS 869572-92-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Variola virus Envelope phospholipase F13 (VARV p37) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection.IDrugs. 2010 Mar;13(3):181-91. Review | |||
| REF 2 | ClinicalTrials.gov (NCT02474589) A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat. | |||
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