Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0MC3R
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| Former ID |
DIB014796
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| Drug Name |
Goxalapladib
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| Synonyms |
Goxalapladib < USAN; 2-[2-[2-(2,3-Difluorophenyl)ethyl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[4'-(trifluoromethyl)biphenyl-4-ylmethyl]acetamide; 677116
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| Drug Type |
Small molecular drug
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| Indication | Arteriosclerosis [ICD-11: BD40; ICD-9: 440] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C40H39F5N4O3
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| Canonical SMILES |
COCCN1CCC(CC1)N(CC2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C(=O)CN4C(=CC(=O)C5=C4N=CC=C5)CCC6=C(C(=CC=C6)F)F
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| InChI |
1S/C40H39F5N4O3/c1-52-23-22-47-20-17-32(18-21-47)48(25-27-7-9-28(10-8-27)29-11-14-31(15-12-29)40(43,44)45)37(51)26-49-33(16-13-30-4-2-6-35(41)38(30)42)24-36(50)34-5-3-19-46-39(34)49/h2-12,14-15,19,24,32H,13,16-18,20-23,25-26H2,1H3
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| InChIKey |
OBJKLVFDRLAGJI-UHFFFAOYSA-N
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| CAS Number |
CAS 412950-27-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet-activating factor acetylhydrolase (PLA2G7) | Target Info | Modulator | [2] |
| KEGG Pathway | Ether lipid metabolism | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Pathway Interaction Database | Lissencephaly gene (LIS1) in neuronal migration and development | |||
| WikiPathways | IL1 and megakaryotyces in obesity | |||
| Synthesis, Secretion, and Deacylation of Ghrelin | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020582) | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020582) | |||
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