Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M9WX
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| Former ID |
DIB000483
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| Drug Name |
AMT-030
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| Synonyms |
AAV gene therapy (AGT, hyperoxaluria), AMT; Adeno-associated virus gene therapy (alanine:glyoxylate aminotransferase, hyperoxaluria), Amsterdam Molecular Therapeutics
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| Indication | Hyperoxaluria [ICD-11: 5C51.2] | Terminated | [1] | |
| Company |
Amsterdam Molecular Therapeutics BV
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Alanine glyoxylate aminotransferase (AGXT) | Target Info | Modulator | [2] |
| KEGG Pathway | Alanine, aspartate and glutamate metabolism | |||
| Glycine, serine and threonine metabolism | ||||
| Glyoxylate and dicarboxylate metabolism | ||||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Carbon metabolism | ||||
| Peroxisome | ||||
| Pathwhiz Pathway | Alanine Metabolism | |||
| Glycine and Serine Metabolism | ||||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| Alanine and aspartate metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024084) | |||
| REF 2 | Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med. 2011 Dec 22;365(25):2357-65. | |||
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