Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M9WM
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| Former ID |
DAP000605
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| Drug Name |
Chlorothiazide
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| Synonyms |
Aldoclor; Alurene; Chloriazid; Chlorosal; Chlorothiazid; Chlorothiazidum; Chlorotiazida; Chlorthiazid; Chlorthiazide; Chlorthiazidum; Chlortiazid; Chlorurit; Chlotride; Chlrosal; Clorotiazida; Clorotiazide; Clotride; Diupres; Diuresal; Diuril; Diurilix; Diurite; Diutrid; Flumen; Minzil; Salisan; Salunil; Saluretil; Saluric; Thiazide; Urinex; Warduzide; Yadalan; Clorotiazide [DCIT]; Component of Aldoclor; Diuril Boluses; C 4911; Chlorothiazidum [INN-Latin]; Clorotiazida [INN-Spanish]; Diuril (TN); Diuril Boluses, Veterinary; Neo-Dema; Sk-chlorothiazide; Chlorothiazide [USAN:INN:BAN]; Diuril, Chlotride, Chlorothiazide; Chlorothiazide (JAN/USP/INN); 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide; 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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| Drug Type |
Small molecular drug
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| Indication | Congestive heart failure [ICD-11: BD10; ICD-10: I50.0] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Oak Pharmaceuticals Inc Sub Akorn Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C7H6ClN3O4S2
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| Canonical SMILES |
C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
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| InChI |
1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
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| InChIKey |
JBMKAUGHUNFTOL-UHFFFAOYSA-N
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| CAS Number |
CAS 58-94-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9664, 542598, 855976, 4970936, 5051008, 7847585, 7978922, 8149249, 10321157, 10528492, 11110950, 11110951, 11335850, 11361089, 11363008, 11365570, 11368132, 11371323, 11373919, 11376294, 11462061, 11466279, 11467399, 11484024, 11486017, 11487970, 11490158, 11492095, 11493948, 15023005, 17389544, 17404817, 22425567, 24278150, 24714733, 26611653, 26680067, 26747285, 26747286, 29221877, 46507032, 47291140, 47291141, 47291142, 47515323, 47515324, 47662287, 47885422, 47959750, 48415760
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| ChEBI ID |
CHEBI:3640
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| ADReCS Drug ID | BADD_D00442 ; BADD_D00443 | |||
| SuperDrug ATC ID |
C03AA04
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| SuperDrug CAS ID |
cas=000058935
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carbonic anhydrase II (CA-II) | Target Info | Inhibitor | [4] |
| KEGG Pathway | Nitrogen metabolism | |||
| Proximal tubule bicarbonate reclamation | ||||
| Collecting duct acid secretion | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| EGFR1 Signaling Pathway | ||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | |||
| Erythrocytes take up oxygen and release carbon dioxide | ||||
| Reversible hydration of carbon dioxide | ||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | |||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | ||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4835). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 084026. | |||
| REF 4 | Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8. | |||
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