Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M5WS
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| Former ID |
DNCL002874
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| Drug Name |
JNJ-16269110
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| Synonyms |
SCHEMBL803531; CHEMBL2103860
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Phase 2 | [1] | |
| Company |
Janssen Research & Development
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| Structure |
 |
Download2D MOL |
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| Formula |
C34H31F3N2O3
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| Canonical SMILES |
COC(=O)C(C1=CC=CC=C1)N2CCC(CC2)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4C5=CC=C(C=C5)C(F)(F)F
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| InChI |
1S/C34H31F3N2O3/c1-42-33(41)31(26-7-3-2-4-8-26)39-21-19-24(20-22-39)23-13-17-28(18-14-23)38-32(40)30-10-6-5-9-29(30)25-11-15-27(16-12-25)34(35,36)37/h2-18,24,31H,19-22H2,1H3,(H,38,40)/t31-/m1/s1
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| InChIKey |
WSYALRNYQFNNGP-WJOKGBTCSA-N
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| CAS Number |
CAS 403989-79-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Microsomal triglyceride transfer protein (MTTP) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Fat digestion and absorption | |||
| Reactome | Chylomicron-mediated lipid transport | |||
| WikiPathways | Statin Pathway | |||
| Lipid digestion, mobilization, and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00672386) A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes. U.S. National Institutes of Health. | |||
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