Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M3TD
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| Former ID |
DIB002958
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| Drug Name |
Org-43902
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| Synonyms |
LH-ago1; ORG-41247; ORG-42619; ORG-43311; SC-20565; Luteinizing hormone receptor (LHR) agonist, NV Organon; Oral LH agonist, Schering-Plough; Low molecular weight luteinizing hormone (LMW LH) receptor agonist, Merck & Co; Luteinizing hormone agonist (oral), Merck & Co; Luteinizing hormone agonist (oral), Schering-Plough
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| Indication | Infertility [ICD-11: GB04; ICD-10: N46; ICD-9: 628] | Phase 1 | [1] | |
| Company |
Organon BioSciences
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Luteinizing hormone receptor (LHCGR) | Target Info | Agonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Ovarian steroidogenesis | ||||
| Prolactin signaling pathway | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Pathwhiz Pathway | Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin | |||
| Pathway Interaction Database | Arf6 signaling events | |||
| Reactome | Hormone ligand-binding receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Ovarian Infertility Genes | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800042073) | |||
| REF 2 | First evidence of ovulation induced by oral LH agonists in healthy female volunteers of reproductive age. J Clin Endocrinol Metab. 2013 Apr;98(4):1558-66. | |||
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