Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M2TG
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| Former ID |
DIB010892
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| Drug Name |
PYM-50028
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| Synonyms |
Cogane; Smilagenin; P-58; P-63
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| Indication | Neurological disorder [ICD-11: 6B60] | Phase 2 | [1] | |
| Company |
Phytopharm
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Brain-derived neurotrophic factor (BDNF) | Target Info | Agonist | [1] |
| KEGG Pathway | MAPK signaling pathway | |||
| cAMP signaling pathway | ||||
| Neurotrophin signaling pathway | ||||
| Huntington's disease | ||||
| Cocaine addiction | ||||
| Alcoholism | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Panther Pathway | Huntington disease | |||
| Metabotropic glutamate receptor group II pathway | ||||
| Pathway Interaction Database | SHP2 signaling | |||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| p75(NTR)-mediated signaling | ||||
| Neurotrophic factor-mediated Trk receptor signaling | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| MAPK Signaling Pathway | ||||
| Spinal Cord Injury | ||||
| BDNF signaling pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| FSH signaling pathway | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB J. 2008 Jul;22(7):2488-97. | |||
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