Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0M2MC
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| Former ID |
DAP000860
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| Drug Name |
Phenmetrazine
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| Synonyms |
Cafilon; Defenmetrazin; Dexphenmetrazine; Fenmetrazin; Fenmetrazina; Oxazimedrine; Phenmetraline; Phenmetrazin; Phenmetrazinum; Preludin hydrochloride; A 66; Psychamine A 66; Defenmetrazin (TN); Fenmetrazin (TN); Fenmetrazina [INN-Spanish]; Oxazimedrine (TN); Phenmetraline (TN); Phenmetrazine [INN:BAN]; Phenmetrazinum [INN-Latin]; Dl-2-Phenyl-3-methyltetrahydro-1,4-oxazine; 2-Fenyl-3-methylmorfolin; 2-Fenyl-3-methylmorfolin [Czech]; 2-Phenyl-3-methylmorpholine; 3-Methyl-2-phenylmorpholine; 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Approved | [1] | |
| Therapeutic Class |
Appetite Depressants
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| Company |
Boehringer Ingelheim GmbH
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H15NO
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| Canonical SMILES |
CC1C(OCCN1)C2=CC=CC=C2
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| InChI |
1S/C11H15NO/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3
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| InChIKey |
OOBHFESNSZDWIU-UHFFFAOYSA-N
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| CAS Number |
CAS 134-49-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9636, 4437709, 7980290, 8152923, 10506941, 15322006, 26757954, 29223846, 46504524, 48416414, 49994179, 50420966, 57322435, 92714657, 95613288, 104307352, 108210008, 124582671, 124893147, 126629462, 128836902, 134223759, 134338139, 134975074, 137089239, 141905910, 143440995, 160964172, 162208475, 163258024, 164174564, 170507515, 174534923, 176265247, 179226016, 184605388, 198935988, 212295757, 223364442, 226420514, 242111128, 249524148, 249933220
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| ChEBI ID |
CHEBI:8067
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine transporter (DAT) | Target Info | Inhibitor | [2] |
| Norepinephrine transporter (NET) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Dopaminergic synapse | |||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Dopaminergic Neurogenesis | ||||
| Parkinsons Disease Pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drug information of Phenmetrazine, 2008. eduDrugs. | |||
| REF 2 | Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7. | |||
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