Drug Information
Drug General Information | Top | |||
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Drug ID |
D0M0RN
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Former ID |
DIB001837
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Drug Name |
SCH-42495
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Synonyms |
N-[2(S)-(Acetylsulfanylmethyl)-3-(2-methylphenyl)propionyl]-L-methionine ethyl ester
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Drug Type |
Small molecular drug
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Indication | Hypotension [ICD-11: BA20-BA21] | Discontinued in Phase 2 | [1] | |
Structure |
Download2D MOL |
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Formula |
C20H29NO4S2
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Canonical SMILES |
CCOC(=O)C(CCSC)NC(=O)C(CC1=CC=CC=C1C)CSC(=O)C
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InChI |
1S/C20H29NO4S2/c1-5-25-20(24)18(10-11-26-4)21-19(23)17(13-27-15(3)22)12-16-9-7-6-8-14(16)2/h6-9,17-18H,5,10-13H2,1-4H3,(H,21,23)/t17-,18+/m1/s1
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InChIKey |
ZVQXPUMRSJGLSF-MSOLQXFVSA-N
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CAS Number |
CAS 136511-43-8
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Neutral endopeptidase (MME) | Target Info | Inhibitor | [2], [3] |
KEGG Pathway | Renin-angiotensin system | |||
Hematopoietic cell lineage | ||||
Protein digestion and absorption | ||||
Alzheimer's disease | ||||
NetPath Pathway | EGFR1 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | Metabolism of Angiotensinogen to Angiotensins | |||
Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Alzheimers Disease |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002070) | |||
REF 2 | Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension. Hypertension. 1993 Jul;22(1):119-26. | |||
REF 3 | The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8. |
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