Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0LT5Y
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| Drug Name |
Piperazine derivative 5
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| Synonyms |
PMID26936077-Compound-16
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| Drug Type |
Small molecular drug
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| Indication | Atopic dermatitis [ICD-11: EA80; ICD-10: L20; ICD-9: 691.8, 692.9] | Patented | [1] | |
| Company |
NeoPharm Co. Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C14H25N3O3
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| Canonical SMILES |
CC(=O)CC(=O)N1CCN(CC1)C(=O)CCCCCN
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| InChI |
1S/C14H25N3O3/c1-12(18)11-14(20)17-9-7-16(8-10-17)13(19)5-3-2-4-6-15/h2-11,15H2,1H3
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| InChIKey |
ISBLYNHHDOKBBQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Proteinase activated receptor 2 (PAR2) | Target Info | Antagonist | [1] |
| Target's Patent Info | Proteinase activated receptor 2 (PAR2) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| African trypanosomiasis | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. | |||
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