Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0LM6D
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| Drug Name |
1,3,4-oxadiazole derivative 1
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| Synonyms |
PMID30107136-Compound-Example37
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| Drug Type |
Small molecule immunotherapy
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| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
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| Structure |
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Download2D MOL |
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| Formula |
C19H26N4O6S
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| Canonical SMILES |
COCCNC(=O)CCC(C1=NN=C(O1)C2=CC=CC=C2OC)NS(=O)(=O)C3CC3
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| InChI |
1S/C19H26N4O6S/c1-27-12-11-20-17(24)10-9-15(23-30(25,26)13-7-8-13)19-22-21-18(29-19)14-5-3-4-6-16(14)28-2/h3-6,13,15,23H,7-12H2,1-2H3,(H,20,24)/t15-/m0/s1
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| InChIKey |
FYAJXXVCAGXKAN-HNNXBMFYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Programmed cell death protein 1 (PD-1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Programmed cell death protein 1 (PD-1) | Target's Patent Info | [1] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| T cell receptor signaling pathway | ||||
| Reactome | PD-1 signaling | |||
| WikiPathways | T-Cell Receptor and Co-stimulatory Signaling | |||
| Costimulation by the CD28 family | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
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