Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L9SN
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| Former ID |
DNC000989
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| Drug Name |
NAN-190
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| Synonyms |
NAN-190; Nan 190; NAN190; SJDOMIRMMUGQQK-UHFFFAOYSA-N; CHEMBL8618; CHEBI:64131; 2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione; 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; 2-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione; 2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindole-1,3-dione; 2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione; 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C23H27N3O3
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| Canonical SMILES |
COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O
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| InChI |
1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3
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| InChIKey |
SJDOMIRMMUGQQK-UHFFFAOYSA-N
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| CAS Number |
CAS 102392-05-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5096910, 8152736, 11111535, 11113562, 14854322, 26751769, 29223528, 47959943, 48035313, 48110624, 50070708, 50104456, 80922047, 85209408, 85788301, 90341187, 103167522, 103856048, 103920452, 104306388, 106801846, 118489674, 124750067, 124880879, 124880880, 124880881, 126722888, 129243807, 135610579, 135650690, 136350487, 137144105, 143722439, 162222851, 162986222, 179235721, 203101922, 223536004, 224218878, 228359247, 250078615
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| ChEBI ID |
CHEBI:64131
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Antagonist | [1] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603. | |||
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