Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L8YY
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| Former ID |
DIB016426
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| Drug Name |
SR-14136
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| Synonyms |
ORL1 ligands (pain); SR-14148; SR-14150; SR-14159; SR-16430; SR-16435; SR-16506; SR-16507; SR-16835; NOP receptor modulators (pain), SRI; ORL1 ligands (pain), SRI; Nociceptin/orphanin FQ modulators (pain), SRI
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Investigative | [1] | |
| Company |
SRI International
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| Structure |
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Download2D MOL |
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| Formula |
C22H25N3O
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| Canonical SMILES |
C1CC2CC(CCN2C(C1)C3=CC=CC=C3)N4C5=CC=CC=C5NC4=O
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| InChI |
1S/C22H25N3O/c26-22-23-19-10-4-5-11-21(19)25(22)18-13-14-24-17(15-18)9-6-12-20(24)16-7-2-1-3-8-16/h1-5,7-8,10-11,17-18,20H,6,9,12-15H2,(H,23,26)/t17-,18-,20+/m1/s1
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| InChIKey |
KMUYAJQKQQUKSQ-GGPKGHCWSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nociceptin receptor (OPRL1) | Target Info | Binder | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). | |||
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