Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L8WH
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| Former ID |
DNC007115
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| Drug Name |
ABT-737
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| Synonyms |
ABT-737; 852808-04-9; ABT 737; ABT737; UNII-Z5NFR173NV; Z5NFR173NV; 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide; CHEMBL376408; C42H45ClN6O5S2; 4-{4-[(4'-Chlorobiphenyl-2-Yl)methyl]piperazin-1-Yl}-N-{[4-({(1r)-3-(Dimethylamino)-1-[(Phenylthio)methyl]propyl}amino)-3-Nitrophenyl]sulfonyl}benzamide
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C42H45ClN6O5S2
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| Canonical SMILES |
CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
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| InChI |
1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1
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| InChIKey |
HPLNQCPCUACXLM-PGUFJCEWSA-N
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| CAS Number |
CAS 852808-04-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16311417, 23409660, 24771379, 42307785, 49700562, 56311704, 56314454, 80047167, 87557472, 92729821, 99003700, 99431768, 103505845, 118043388, 124756925, 125163732, 126582692, 126723510, 134344320, 135262602, 135727387, 135727816, 136367451, 136920254, 137220587, 137507903, 143499176, 152236756, 152258854, 152344158, 160647704, 162011590, 162037377, 162202715, 163391231, 163685667, 163842211, 164045164, 164194130, 164834713, 172087028, 174007025, 174316178, 177748628, 184814009, 198934891, 223683207, 226522540, 241155185, 242585323
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem. 2007 Feb 22;50(4):641-62. | |||
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