Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L8QX
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| Former ID |
DNC000740
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| Drug Name |
Homorisedronate
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| Synonyms |
NE 58051; 104261-69-0; NE-58051; CHEMBL293522; [1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyl]bis(phosphonic acid); HRX; AC1L2TXU; SCHEMBL8710665; 3-(3-Pyridyl)-1-hydroxypropylidene bisphosphonic acid; (1-Hydroxy-3-(3-pyridinyl)propylidene)bisphosphonic acid; DTXSID70146363; 1-hydroxy-3-(3-pyridyl)propylidene-1,1-bisphosphonic acid; ILROXFQHACCDLA-UHFFFAOYSA-N; BDBM50098382; 3-(3-Hydroxy-3,3-bis-phosphono-propyl)-pyridinium; 3-(3-pyridyl)-1-hydroxy-propane-1,1-bisphosphonate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H13NO7P2
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| Canonical SMILES |
C1=CC(=CN=C1)CCC(O)(P(=O)(O)O)P(=O)(O)O
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| InChI |
1S/C8H13NO7P2/c10-8(17(11,12)13,18(14,15)16)4-3-7-2-1-5-9-6-7/h1-2,5-6,10H,3-4H2,(H2,11,12,13)(H2,14,15,16)
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| InChIKey |
ILROXFQHACCDLA-UHFFFAOYSA-N
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| CAS Number |
CAS 104261-69-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Influenza A | ||||
| HTLV-I infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
| SREBP signalling | ||||
| Cholesterol Biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem. 2001 Sep 7;276(36):33930-7. | |||
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