Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L8HB
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Drug Name |
MEDI9197
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Synonyms |
RRTPWQXEERTRRK-UHFFFAOYSA-N; UNII-16598XQ2BT; 16598XQ2BT; 1359993-59-1; N-(4-((4-Amino-2-butyl-1H-imidazo(4,5-C)quinolin-1-yl)oxy)butyl)octadecanamide; N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide; SCHEMBL671176; MEDI-9197; AKOS032946368; Octadecanamide, N-(4-((4-amino-2-butyl-1H-imidazo(4,5-C)quinolin-1-yl)oxy)butyl)-
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
Company |
MedImmune Gaithersburg, MD
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Structure |
Download2D MOL |
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Formula |
C36H59N5O2
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Canonical SMILES |
CCCCCCCCCCCCCCCCCC(=O)NCCCCON1C(=NC2=C1C3=CC=CC=C3N=C2N)CCCC
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InChI |
1S/C36H59N5O2/c1-3-5-7-8-9-10-11-12-13-14-15-16-17-18-19-27-33(42)38-28-22-23-29-43-41-32(26-6-4-2)40-34-35(41)30-24-20-21-25-31(30)39-36(34)37/h20-21,24-25H,3-19,22-23,26-29H2,1-2H3,(H2,37,39)(H,38,42)
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InChIKey |
RRTPWQXEERTRRK-UHFFFAOYSA-N
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CAS Number |
CAS 1359993-59-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Toll-like receptor 7 (TLR7) | Target Info | Agonist | [1] |
Toll-like receptor 8 (TLR8) | Target Info | Agonist | [1] | |
KEGG Pathway | Toll-like receptor signaling pathway | |||
Measles | ||||
Influenza A | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Leptin Signaling Pathway | ||||
Panther Pathway | Toll receptor signaling pathway | |||
Reactome | Trafficking and processing of endosomal TLR | |||
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | ||||
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | ||||
MyD88 dependent cascade initiated on endosome | ||||
WikiPathways | Toll-like receptor signaling pathway | |||
Toll-Like Receptors Cascades | ||||
MyD88 dependent cascade initiated on endosome | ||||
Trafficking and processing of endosomal TLR | ||||
Regulation of toll-like receptor signaling pathway |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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