Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L7AO
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| Former ID |
DNC014875
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| Drug Name |
Gababutin
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| Synonyms |
Gababutin; CHEMBL610734; 60142-99-6; Cyclopentaneacetic acid, 1-(aminomethyl)-; 2-[1-(aminomethyl)cyclopentyl]acetic Acid; SCHEMBL25615; CTK2F1329; DTXSID70432495; ZINC34016806; BDBM50304691
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H15NO2
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| Canonical SMILES |
C1CCC(C1)(CC(=O)O)CN
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| InChI |
1S/C8H15NO2/c9-6-8(5-7(10)11)3-1-2-4-8/h1-6,9H2,(H,10,11)
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| InChIKey |
MKGSCDBHUPQQMX-UHFFFAOYSA-N
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| CAS Number |
CAS 60142-99-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | MAPK signaling pathway | |||
| Cardiac muscle contraction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Oxytocin signaling pathway | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||
| WikiPathways | Arrhythmogenic Right Ventricular Cardiomyopathy | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and in vivo evaluation of 3-substituted gababutins. Bioorg Med Chem Lett. 2010 Jan 1;20(1):362-5. | |||
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