Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L5YC
|
|||
| Former ID |
DNC011818
|
|||
| Drug Name |
8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine
|
|||
| Synonyms |
8-Methoxy-2-aminotetralin; 3880-77-1; 8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine; 8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine; CHEMBL26688; ACMC-20msdp; ACMC-20mscg; 2-amino-8-methoxytetralin; 8-methoxytetralin-2-amine; 8-methoxy-2-amino-tetralin; 2-Naphthalenamine,1,2,3,4-tetrahydro-8-methoxy-, (2R)-; 2-Naphthalenamine,1,2,3,4-tetrahydro-8-methoxy-, (2S)-; SCHEMBL266921; CTK4I0515; 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-8-METHOXY-; RVKOHSCTEHZRRT-UHFFFAOYSA-N; MFCD00906373; BDBM50016733; AKOS022393176; FCH1122360
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C11H15NO
|
|||
| Canonical SMILES |
COC1=CC=CC2=C1CC(CC2)N
|
|||
| InChI |
1S/C11H15NO/c1-13-11-4-2-3-8-5-6-9(12)7-10(8)11/h2-4,9H,5-7,12H2,1H3
|
|||
| InChIKey |
RVKOHSCTEHZRRT-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 3880-77-1
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.