Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L5BW
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Former ID |
DIB019909
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Drug Name |
GlaxoSmithKline compound 6i
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
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Formula |
C25H24Cl2N2O
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Canonical SMILES |
CCC1C(C(C2=CC=CC=C2N1C(=O)C3=CC(=CC(=C3)Cl)Cl)NC4=CC=CC=C4)C
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InChI |
1S/C25H24Cl2N2O/c1-3-22-16(2)24(28-20-9-5-4-6-10-20)21-11-7-8-12-23(21)29(22)25(30)17-13-18(26)15-19(27)14-17/h4-16,22,24,28H,3H2,1-2H3/t16-,22-,24+/m1/s1
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InChIKey |
DKLLTFTXYHJXHK-OAEOJWKDSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | P2Y purinoceptor 1 (P2RY1) | Target Info | Antagonist | [1] |
KEGG Pathway | Rap1 signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Platelet activation | ||||
Reactome | G alpha (q) signalling events | |||
P2Y receptors | ||||
ADP signalling through P2Y purinoceptor 1 | ||||
WikiPathways | Nucleotide GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Signal amplification | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6222-6. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5806). |
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