Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L3DK
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| Former ID |
DAP001544
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| Drug Name |
Vildagliptin
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| Synonyms |
Equa; Galvu; Galvus; Jalra; Xiliarx; Galvus (TN); Vidagliptin (see Vildagliptin); Vildagliptin (JAN/USAN/INN); (2S)-(((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile; (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile; 1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile; 2-Pyrrolidinecarbonitrile, 1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S)-(9CI)
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| Drug Type |
Small molecular drug
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| Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Approved | [1], [2] | |
| Company |
Novartis
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| Structure |
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Download2D MOL |
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| Formula |
C17H25N3O2
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| Canonical SMILES |
C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N
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| InChI |
1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
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| InChIKey |
SYOKIDBDQMKNDQ-XWTIBIIYSA-N
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| CAS Number |
CAS 274901-16-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12015446, 14849686, 14898545, 17194948, 43529907, 46512217, 50459774, 51091422, 57371966, 99443227, 103381660, 104178744, 114788130, 118314324, 121147405, 124772155, 126651432, 129307316, 134358368, 135683855, 136375110, 137004291, 139563570, 152037539, 152159633, 160967824, 172085080, 172914664, 174477837, 175266579, 175426398, 178102929, 186021611, 196105655, 210275077, 210280715, 224646668, 226406746, 249810559, 251883214, 252032033, 252160316, 252216578, 252308983
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| ChEBI ID |
CHEBI:135285
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| ADReCS Drug ID | BADD_D02357 | |||
| SuperDrug ATC ID |
A10BH02
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dipeptidyl peptidase 4 (DPP-4) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Protein digestion and absorption | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6310). | |||
| REF 2 | Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. | |||
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