Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L1FN
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| Former ID |
DIB013641
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| Drug Name |
Emfilermin
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| Synonyms |
AM-424; Leukemia inhibitory factor, AMRAD; RhLIF, AMRAD; RhLIF, Serono; Recombinant LIF protein, AMRAD/Serono; R-LIF, AMRAD/Serono
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| Indication | Infertility [ICD-11: GB04; ICD-10: N46; ICD-9: 628] | Phase 1/2 | [1] | |
| Company |
Zenyth Therapeutics Ltd
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leukemia inhibitory factor receptor (LIFR) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Signaling pathways regulating pluripotency of stem cells | ||||
| Jak-STAT signaling pathway | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Leptin Signaling Pathway | ||||
| WikiPathways | Oncostatin M Signaling Pathway | |||
| Adipogenesis | ||||
| Physiological and Pathological Hypertrophy of the Heart | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00504530) r-hLIF for Improving Embryo Implantation in IVF. U.S. National Institutes of Health. | |||
| REF 2 | Population pharmacokinetic modelling of Emfilermin (recombinant human leukaemia inhibitory factor, r-hLIF) in healthy postmenopausal women and in infertile patients undergoing in vitro fertilization and embryo transfer. Br J Clin Pharmacol. 2004 May; 57(5): 576-585. | |||
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