Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L1DP
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| Former ID |
DCL000675
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| Drug Name |
ABT-089
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| Synonyms |
Pozanicline; A 94224; ABT 089; Pozanicline (USAN); (R)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine; 2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine; 2-Methyl-3-(2S-pyrrolidinylmethoxy)pyridine; 2-methyl-3-[[(2R)-pyrrolidin-2-yl]methoxy]pyridine; 2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD-11: 6B00-6B0Z] | Discontinued in Phase 2 | [1] | |
| Attention deficit hyperactivity disorder [ICD-11: 6A05.Z] | Discontinued in Phase 2 | [1] | ||
| Dementia [ICD-11: 6D80-6D86] | Discontinued in Phase 2 | [1] | ||
| Schizophrenia [ICD-11: 6A20] | Discontinued in Phase 2 | [1] | ||
| Company |
Abbott Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H16N2O
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| Canonical SMILES |
CC1=C(C=CC=N1)OCC2CCCN2
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| InChI |
1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1
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| InChIKey |
YRVIKLBSVVNSHF-JTQLQIEISA-N
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| CAS Number |
CAS 161417-03-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for attention-deficit/hyperactivity disorder. Expert Opin Emerg Drugs. 2007 Sep;12(3):423-34. | |||
| REF 2 | Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain.Biochem Pharmacol.2009 Oct 1;78(7):795-802. | |||
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