Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0KW3Z
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| Former ID |
DIB000875
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| Drug Name |
GORALATIDE
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| Synonyms |
AcSDKP; Seraspenide; BIM-32001; Goralatide; Acetyl-seryl-aspartyl-lysyl-proline
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| Drug Type |
Small molecular drug
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| Indication | Constitutional neutropenia [ICD-11: 4B00.0] | Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H33N5O9
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| Canonical SMILES |
CC(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)O
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| InChI |
1S/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/t12-,13-,14-,15-/m0/s1
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| InChIKey |
HJDRXEQUFWLOGJ-AJNGGQMLSA-N
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| CAS Number |
CAS 120081-14-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cyclin D1 synthesis (CCND1 synthesis) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Thymosin beta4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int. 2013 December; 84(6): 10.1038/ki.2013.209. | |||
| REF 2 | Reduction of heat-induced haemotoxicity in a hyperthermic purging protocol of murine acute myeloid leukaemic stem cells by AcSDKP. Br J Haematol. 1997 Dec;99(3):692-8. | |||
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