Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0KG5D
|
|||
| Former ID |
DNCL002671
|
|||
| Drug Name |
Mapatumumab
|
|||
| Drug Type |
Monoclonal antibody
|
|||
| Indication | Non-small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 155] | Phase 2 | [1] | |
| Company |
Human Genome Sciences
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TRAIL receptor 1 (TRAIL-R1) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Apoptosis | ||||
| Natural killer cell mediated cytotoxicity | ||||
| Measles | ||||
| Influenza A | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Apoptosis signaling pathway | |||
| p53 pathway | ||||
| Pathway Interaction Database | TRAIL signaling pathway | |||
| Direct p53 effectors | ||||
| Caspase Cascade in Apoptosis | ||||
| Reactome | Ligand-dependent caspase activation | |||
| Regulation by c-FLIP | ||||
| RIPK1-mediated regulated necrosis | ||||
| CASP8 activity is inhibited | ||||
| Dimerization of procaspase-8 | ||||
| TRAIL signaling | ||||
| WikiPathways | miR-targeted genes in lymphocytes - TarBase | |||
| Apoptosis Modulation and Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00094848) Study of TRM-1 (TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL). U.S. National Institutes of Health. | |||
| REF 2 | National Cancer Institute Drug Dictionary (drug id 486626). | |||
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