Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0KA7I
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| Drug Name |
PMID30107136-Compound-Example7
|
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| Drug Type |
Small molecule immunotherapy
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| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
BRISTOL-MYERS SQUIBB COMPANY
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| Structure |
 |
Download2D MOL |
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| Formula |
C43H49ClN4O6
|
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| Canonical SMILES |
CC1=C(C=CC=C1C2=C(C(=CC=C2)OCCCN3CCC(CC3)O)C)COC4=C(C=C(C(=C4)OCC5=CC(=CN=C5)C#N)CN6CCCCC6C(=O)O)Cl
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| InChI |
1S/C43H49ClN4O6/c1-29-33(8-5-9-36(29)37-10-6-12-40(30(37)2)52-19-7-15-47-17-13-35(49)14-18-47)28-54-42-22-41(53-27-32-20-31(23-45)24-46-25-32)34(21-38(42)44)26-48-16-4-3-11-39(48)43(50)51/h5-6,8-10,12,20-22,24-25,35,39,49H,3-4,7,11,13-19,26-28H2,1-2H3,(H,50,51)
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| InChIKey |
VDKPFVAEXSRQOY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target Info | Inhibitor | [1] |
| Target's Patent Info | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target's Patent Info | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
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