Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K4HW
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| Former ID |
DNC004426
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| Drug Name |
N-DESMETHYLCLOZAPINE
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| Drug Type |
Small molecular drug
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| Indication | Schizoaffective disorder [ICD-11: 6A21] | Phase 2 | [1] | |
| Schizophrenia [ICD-11: 6A20] | Phase 2 | [1] | ||
| Structure |
 |
Download2D MOL |
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| Formula |
C17H17ClN4
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| Canonical SMILES |
C1CN(CCN1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
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| InChI |
1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
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| InChIKey |
JNNOSTQEZICQQP-UHFFFAOYSA-N
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| CAS Number |
CAS 6104-71-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
631807, 5566057, 11113852, 14776686, 24893957, 26752025, 29221975, 32084983, 53788089, 56311660, 57321482, 79643652, 85788311, 90341107, 91612247, 92712278, 103221584, 103808667, 103858519, 104014767, 104301709, 117464490, 121361302, 125544710, 126630134, 126656816, 128300673, 134341631, 135061653, 135610864, 135650395, 135698054, 136350449, 137123192, 139649952, 141645434, 152100640, 162023011, 162221239, 162880946, 163564402, 164839413, 175612399, 179236053, 184589776, 198961388, 198991745, 224094687, 226973046, 227063804
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| ChEBI ID |
CHEBI:64050
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 333). | |||
| REF 2 | N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarin... Neuropsychopharmacology. 2005 Nov;30(11):1986-95. | |||
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