Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0K4BI
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| Drug Name |
Jte 013
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| Synonyms |
Jte 013; JTE-013; 383150-41-2; CHEMBL1368758; S1P2 Receptor Antagonist, JTE-013; N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide; 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; 1-(1,3-Dimethyl-4-isopropyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-(3,5-dichloro-4-pyridinyl)-semicarbazide; pyrazolopyridine analog; C17H19Cl2N7O; GTPL2917; SCHEMBL5911940; CHEBI:92763; CTK8F0047; SYN5010; DTXSID60436982; AOB1935; HMS3650O12;
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C17H19Cl2N7O
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| Canonical SMILES |
CC1=NN(C2=C1C(=CC(=N2)NNC(=O)NC3=CC(=NC(=C3)Cl)Cl)C(C)C)C
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| InChI |
1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
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| InChIKey |
RNSLRQNDXRSASX-UHFFFAOYSA-N
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| CAS Number |
CAS 383150-41-2
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:92763
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sphingosine-1-phosphate receptor 2 (S1PR2) | Target Info | Inhibitor | [2] |
| Target's Patent Info | Sphingosine-1-phosphate receptor 2 (S1PR2) | Target's Patent Info | [2] | |
| KEGG Pathway | Sphingolipid signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Pathway Interaction Database | S1P3 pathway | |||
| Sphingosine 1-phosphate (S1P) pathway | ||||
| S1P2 pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Lysosphingolipid and LPA receptors | ||||
| WikiPathways | Signal Transduction of S1P Receptor | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2917). | |||
| REF 2 | Sphingosine 1-phosphate receptor antagonists. US9663511. | |||
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