Drug Information
Drug General Information | Top | |||
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Drug ID |
D0K3KM
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Drug Name |
PMID25666693-Compound-148
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Drug Type |
Small molecular drug
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Indication | Cancer related pain [ICD-11: MG30; ICD-10: R52.1, R52.2] | Patented | [1] | |
Inflammatory pain [ICD-11: MG30.42; ICD-10: R52, G89] | Patented | [1] | ||
Neuropathic pain [ICD-11: 8E43.0] | Patented | [1] | ||
Osteoarthritis pain [ICD-11: MG30.31] | Patented | [1] | ||
Company |
Xention Ltd
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Structure |
Download2D MOL |
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Formula |
C23H19F2NO2
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Canonical SMILES |
C1CC2=C(CC1O)C(=CC=C2)NC(=O)C3=CC=C(C=C3)C4=CC(=C(C=C4)F)F
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InChI |
1S/C23H19F2NO2/c24-20-11-9-17(12-21(20)25)14-4-6-16(7-5-14)23(28)26-22-3-1-2-15-8-10-18(27)13-19(15)22/h1-7,9,11-12,18,27H,8,10,13H2,(H,26,28)
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InChIKey |
BBXIMYHEGLSHKN-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [1] |
Target's Patent Info | Transient receptor potential cation channel V1 (TRPV1) | Target's Patent Info | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Inflammatory mediator regulation of TRP channels | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
Reactome | TRP channels |
References | Top | |||
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REF 1 | Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. |
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