Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K0IS
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| Former ID |
DIB007295
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| Drug Name |
Polyglutamate camptothecin
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| Synonyms |
CT-2106; PG-interferon; Polyglutamate camptothecin, Cell Therapeutics; Polyglutamate-camptothecin; CPT-Gly-PG; Camptothecin-glycine-polyglutamate; PG-CPT, Cell Therapeutics; PG-camptothecin, CT; Polyglutamate-linked anticancer agents, Cell Therapeutics; PG-G-CSF, Cell Therapeutics
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [1] | |
| Company |
Cell Therapeutics Inc
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [2] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00291837) CT-2106 for the Second Line Treatment of Ovarian Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802. | |||
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