Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JQ7Y
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| Former ID |
DAP001218
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| Drug Name |
Ximelagatran
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| Synonyms |
Exanta; Exarta; H 376/95; Ximelagatran [USAN:INN]; 192939-46-1; H 376-95; H 37695; Glycine, N-((1)1-cyclohexyl-2-((2)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-, ethyl ester; NCGC00183598-01; Ethyl (((1R)-1-cyclohexyl-2-((2S)-2-((4-(hydroxycarbamimidoyl)benzyl)carbamoyl)azetidin-1-yl-2-oxoethyl)amino)acetate; Glycine, N-((1R)-1-cyclohexyl-2-((2S)-2-((((4-(hydroxyamino)iminomethyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)-2-oxoethyl)-, ethyl ester; H 376 95; Exanta (TN); Exarta (TN); Xi-melagatran; H-376/95; Ximelagatran (JAN/USAN/INN); Glycine, N-((1)1-cyclohexyl-2-((2)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester; Glycine, N-((1R)1-cyclohexyl-2-((2S)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester; Glycine, N-((1R)-1-cyclohexyl-2-((2S)-2-((((4-((hydroxyamino)iminomethyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)-2-oxoethyl)-, ester ester; H376/95
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| Drug Type |
Small molecular drug
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| Indication | Coagulation defect [ICD-11: 3B10.0; ICD-10: I80-I82] | Withdrawn from market | [1], [2] | |
| Therapeutic Class |
Anticoagulants
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| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H35N5O5
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| Canonical SMILES |
CCOC(=O)CNC(C1CCCCC1)C(=O)N2CCC2C(=O)NCC3=CC=C(C=C3)C(=NO)N
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| InChI |
1S/C24H35N5O5/c1-2-34-20(30)15-26-21(17-6-4-3-5-7-17)24(32)29-13-12-19(29)23(31)27-14-16-8-10-18(11-9-16)22(25)28-33/h8-11,17,19,21,26,33H,2-7,12-15H2,1H3,(H2,25,28)(H,27,31)/t19-,21+/m0/s1
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| InChIKey |
ZXIBCJHYVWYIKI-PZJWPPBQSA-N
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| CAS Number |
CAS 192939-46-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7849043, 12015148, 14785299, 14858738, 14883129, 14883130, 23997623, 44712163, 46509040, 49973459, 57372958, 79267685, 87225336, 124894453, 134338458, 135106952, 137002923, 137726685, 140950577, 142578696, 144207182, 160645186, 160967831, 164235510, 164766173, 180370510, 226396762, 226396763, 233586233, 251971104
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| ChEBI ID |
CHEBI:136702
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| SuperDrug ATC ID |
B01AE05
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| SuperDrug CAS ID |
cas=192939461
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6381). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Ximelagatran increases membrane fluidity and changes membrane lipid composition in primary human hepatocytes. Toxicol In Vitro. 2009 Oct;23(7):1305-10. | |||
| REF 4 | New anticoagulants. Am Heart J. 2001 Aug;142(2 Suppl):S3-8. | |||
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