Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0J6XC
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| Former ID |
DIB018046
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| Drug Name |
tiratricol
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| Synonyms |
TRIAC; 3,3',5-triiodothyroacetic acid
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| Drug Type |
Small molecular drug
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| Indication | Wound healing [ICD-11: EL8Y] | Clinical trial | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C14H9I3O4
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| Canonical SMILES |
C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O
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| InChI |
1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
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| InChIKey |
UOWZUVNAGUAEQC-UHFFFAOYSA-N
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| CAS Number |
CAS 51-24-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
827844, 827845, 827846, 827962, 855525, 4401016, 7885356, 8153574, 10321449, 11112109, 11466230, 11467350, 11485840, 14912191, 24900466, 26737090, 26737092, 26737109, 26737501, 29224836, 46504696, 46518914, 47349482, 47943909, 48019053, 48094654, 48426110, 49698385, 50100372, 50610406, 51091552, 53788806, 56261036, 57322967, 57654700, 85756745, 85788050, 91722578, 92125149, 103219116, 103913943, 104310301, 119526441, 121362089, 121362820, 124772192, 124881906, 124881907, 124881908, 126408229
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides ovatus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 2.72E-03). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 2.18E-03). | |||
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Studied Microbe: Parabacteroides distasonis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 9.71E-04). | |||
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Studied Microbe: Parabacteroides merdae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 3.19E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 7.23E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 6.22E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 5.33E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 3.49E-06). | |||
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Studied Microbe: Clostridioides difficile
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 1.27E-04). | |||
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Studied Microbe: Clostridium perfringens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 1.06E-05). | |||
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Studied Microbe: Coprococcus comes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 8.94E-03). | |||
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Studied Microbe: Lacrimispora saccharolytica
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 3.15E-04). | |||
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Studied Microbe: Roseburia intestinalis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 8.09E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Streptococcus salivarius
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Tiratricol, 3,3',5-triiodothyroacetic acid (adjusted p-values: 1.73E-04). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thyroid hormone receptor alpha (THRA) | Target Info | Agonist | [3] |
| Thyroid hormone receptor beta (THRB) | Target Info | Agonist | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Thyroid hormone signaling pathway | ||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Endochondral Ossification | |||
| Nuclear Receptors | ||||
| SIDS Susceptibility Pathways | ||||
| Hematopoietic Stem Cell Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2637). | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34. | |||
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