Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J6LN
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| Former ID |
DIB012620
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| Drug Name |
Etazolate
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| Synonyms |
Etazolate hydrochloride; EHT-0202; SQ-20009
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| Drug Type |
Small molecular drug
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| Indication | Neurodegenerative disorder [ICD-11: 8A20-8A23] | Phase 2 | [1], [2] | |
| Company |
Exonhit
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H19N5O2
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| Canonical SMILES |
CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC
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| InChI |
1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18)
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| InChIKey |
OPQRBXUBWHDHPQ-UHFFFAOYSA-N
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| CAS Number |
CAS 51022-77-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
794671, 5208061, 8152079, 11111137, 11113501, 12012723, 15096768, 29222416, 47365322, 48334619, 50064829, 50104411, 57321695, 58106948, 80244455, 85085895, 85787205, 90341463, 92309184, 103397983, 103820233, 104303041, 117578050, 124749717, 124880016, 124880017, 135001669, 135727535, 137102547, 143338399, 162092075, 162843747, 164809678, 176484523, 178103908, 179148556, 184588371, 198942147, 221672888, 223454391, 226494857, 250113106
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| ChEBI ID |
CHEBI:93135
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7336). | |||
| REF 2 | Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem. 2008 Jul;106(1):392-404. | |||
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