Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J5PL
|
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| Former ID |
DNC002069
|
|||
| Drug Name |
ISIS 134528
|
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| Drug Type |
Antisense drug
|
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Company |
Isis Pharmaceuticals
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Caspase 6 messenger RNA (CASP6 mRNA) | Target Info | . | [1] |
| KEGG Pathway | Apoptosis | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Direct p53 effectors | |||
| p75(NTR)-mediated signaling | ||||
| C-MYB transcription factor network | ||||
| HIV-1 Nef: Negative effector of Fas and TNF-alpha | ||||
| Caspase Cascade in Apoptosis | ||||
| Reactome | Apoptotic cleavage of cellular proteins | |||
| Caspase-mediated cleavage of cytoskeletal proteins | ||||
| WikiPathways | Apoptosis Modulation by HSP70 | |||
| FAS pathway and Stress induction of HSP regulation | ||||
| Apoptosis | ||||
| Parkinsons Disease Pathway | ||||
| Apoptotic execution phase | ||||
| Apoptosis Modulation and Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | US patent application no. 6,566,135, Antisense modulation of caspase 6 expression. | |||
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