Drug Information
Drug General Information | Top | |||
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Drug ID |
D0J2KV
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Former ID |
DAP000497
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Drug Name |
Propafenone
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Synonyms |
Propafenona; Propafenonum; Rythmol; Propafenon Hexal; Propafenon hexal (TN); Propafenona [INN-Spanish]; Propafenone (INN); Propafenone [INN:BAN]; Propafenone-HCl; Propafenonum [INN-Latin]; Rythmol SR (TN); Rytmonorm (TN); 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone; 1-(2-(2-Hydroxy-3-propylaminopropoxy)phenyl)-3-phenylpropan-1-one; 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride; 1-[2-(2-Hydroxy-3-[propylamino]-propoxy)phenyl]-3-phenyl-1-propanone; 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
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Drug Type |
Small molecular drug
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Indication | Tachyarrhythmias [ICD-11: BC71; ICD-10: I49, I49.8] | Approved | [1], [2] | |
Therapeutic Class |
Antiarrhythmic Agents
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Company |
Reliant Pharmaceuticals
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Structure |
Download2D MOL |
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Formula |
C21H27NO3
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Canonical SMILES |
CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
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InChI |
1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
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InChIKey |
JWHAUXFOSRPERK-UHFFFAOYSA-N
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CAS Number |
CAS 54063-53-5
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PubChem Compound ID | ||||
PubChem Substance ID |
9585, 5363963, 8153039, 11336081, 11361320, 11364506, 11367068, 11369630, 11373069, 11373956, 11377792, 11462292, 11466527, 11467647, 11485341, 11486054, 11489419, 11491720, 11492024, 11495426, 14900354, 24278636, 26752315, 26752316, 29224010, 46504529, 47291199, 47291200, 47440332, 47440333, 47589059, 47736554, 47810815, 47959826, 48035202, 48035203, 49698950, 50024038, 50105251, 50105252, 57322533, 74963632, 85088939, 85788247, 85788874, 90341088, 92308765, 92309881, 96025121, 99300795
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ChEBI ID |
CHEBI:63619
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ADReCS Drug ID | BADD_D01856 ; BADD_D01857 | |||
SuperDrug ATC ID |
C01BC03
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SuperDrug CAS ID |
cas=054063535
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Target and Pathway | Top | |||
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Target(s) | Voltage-gated sodium channel (Nav) | Target Info | Modulator | [3] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2561). | |||
REF 2 | New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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