Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J1VY
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| Former ID |
DAP000608
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| Drug Name |
Entacapone
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| Synonyms |
Comtan; Comtess; Entacapona; Entacaponum; Novartis brand of entacapone; Orion brand of entacapone; KB475572; OR 611; COM-998; Comtan (TN); Entacapona [INN-Spanish]; Entacapone [USAN:INN]; Entacaponum [INN-Latin]; OR-611; Stalevo (TN); Entacapone (JAN/USAN/INN); N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide; (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide; (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; (E)-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-N,N-diethyl-prop-2-enamide; (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide; (E)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide; 2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Approved | [1], [2] | |
| Therapeutic Class |
Antiparkinson Agents
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| Company |
Norvatis Phamaceuticals Corporation
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H15N3O5
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| Canonical SMILES |
CCN(CC)C(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O)[O-])C#N
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| InChI |
1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
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| InChIKey |
JRURYQJSLYLRLN-BJMVGYQFSA-N
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| CAS Number |
CAS 130929-57-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10145, 7847846, 7979169, 8616509, 11528716, 12014660, 14776335, 26757974, 39290001, 46508734, 49658624, 50064207, 50214283, 53790856, 57358005, 92308972, 92719407, 93166184, 103248957, 104004044, 113854525, 119504915, 121682934, 124893160, 126530712, 126592033, 126620827, 126653084, 126666453, 131297374, 134337899, 135017133, 135032923, 137001453, 141610450, 144115941, 144205737, 152104428, 160963840, 163620784, 163686109, 164814929, 164840953, 170464850, 172917348, 175268297, 175610943, 176484081, 177748942, 178103260
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| ChEBI ID |
CHEBI:4798
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| ADReCS Drug ID | BADD_D00773 | |||
| SuperDrug ATC ID |
N04BX02
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| SuperDrug CAS ID |
cas=116314671
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -6.104; p = 0.015). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -6.539; p = 0.012). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -6.878; p = 0.009). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -7.363; p = 0.011). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -6.579; p = 0.023). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -7.004; p = 0.016). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -7.877; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -5.788; p = 0.009). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -7.839; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -7.393; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -6.77; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -6.56; p = 0.009). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -6.334; p = 0.004). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -7.342; p = 0.005). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -2.258; p = 0.003). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -5.281; p = 0.007). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -6.588; p = 0.01). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -6.58; p = 0.006). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -6.42; p = 0.003). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -7.548; p = 0.008). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -7.194; p = 0.017). | |||
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Studied Microbe: Bacteroides WH2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides WH2 (log2FC = -5.842; p = 0.019). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -7.315; p = 0.006). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Odoribacter splanchnicus (log2FC = -7.255; p = 0.015). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -7.631; p = 0.004). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -7.445; p = 0.018). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -6.892; p = 0.014). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Pretovella copri DSM 18205 (log2FC = -7.099; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -1.053; p = 0.006). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -6.995; p = 0.012). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -4.665; p = 0.01). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bifidobacterium ruminantium (log2FC = -0.8; p = 0.027). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -4.106; p = 0.02). | |||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -6.254; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -1.83; p = 0.015). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -0.38; p = 0.005). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Proteus penneri ATCC 35198 (log2FC = -0.543; p = 0.032). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -6.594; p = 0.005). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -7.066; p = 0.005). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -6.135; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Anaerostipes sp. (log2FC = -6.862; p = 0.007). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -6.532; p = 0.012). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -1.282; p = 0.001). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Blautia hansenii DSM20583 (log2FC = -6.15; p = 0.009). | |||
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Studied Microbe: Blautia luti DSM 14534
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Blautia luti DSM 14534 (log2FC = -6.375; p = 0.006). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -6.063; p = 0.008). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -6.865; p = 0.017). | |||
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Studied Microbe: Clostridium difficile 120
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium difficile 120 (log2FC = -6.006; p = 0.009). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -4.731; p = 0.017). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -6.508; p = 0.032). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium sp. (log2FC = -6.246; p = 0.006). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -6.762; p = 0.017). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -5.445; p = 0.016). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -7.119; p = 0.006). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -7.008; p = 0.003). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -6.365; p = 0.009). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Eubacterium hallii DSM3353 (log2FC = -6.964; p = 0.004). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -6.076; p = 0.01). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -7.171; p = 0.01). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Roseburia intestinalis L1-82 (log2FC = -6.213; p = 0.004). | |||
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Studied Microbe: Ruminococcus gnavus ATCC 29149
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -6.121; p = 0.007). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -6.7; p = 0.013). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -2.65; p = 0.012). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -6.066; p = 0.012). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis V583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Enterococcus faecalis V583 (log2FC = -6.481; p = 0.015). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -5.636; p = 0.02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -1.034; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
|
Studied Microbe: Victivallis vadensis ATCC BAA-548
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -3.775; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [4] | |||
| Metabolic Reaction | Nitroreduction | |||
| Experimental Method | High-throughput screening | |||
| Description | Entacapone can be metabolized by gut microbiota through nitroreduction. | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides vulgatus
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Entacapone (adjusted p-values: 6.75E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
|
Studied Microbe: Collinsella aerofaciens
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Entacapone (adjusted p-values: 9.15E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Blautia obeum
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Entacapone (adjusted p-values: 3.71E-06). | |||
|
Studied Microbe: Coprococcus comes
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Entacapone (adjusted p-values: 2.07E-04). | |||
|
Studied Microbe: Dorea formicigenerans
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Entacapone (adjusted p-values: 2.06E-05). | |||
|
Studied Microbe: Enterocloster bolteae
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Entacapone (adjusted p-values: 7.10E-06). | |||
|
Studied Microbe: Eubacterium eligens
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Entacapone (adjusted p-values: 3.96E-03). | |||
|
Studied Microbe: Ruminococcus bromii
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Entacapone (adjusted p-values: 2.87E-05). | |||
|
Studied Microbe: Ruminococcus torques
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Entacapone (adjusted p-values: 7.66E-06). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Catechol-O-methyl-transferase (COMT) | Target Info | Inhibitor | [6], [7] |
| BioCyc | L-dopa degradation | |||
| Dopamine degradation | ||||
| Noradrenaline and adrenaline degradation | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Tyrosine metabolism | ||||
| Metabolic pathways | ||||
| Dopaminergic synapse | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Dopamine receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Tyrosine Metabolism | |||
| WikiPathways | Methylation Pathways | |||
| Metapathway biotransformation | ||||
| Estrogen metabolism | ||||
| Biogenic Amine Synthesis | ||||
| Dopamine metabolism | ||||
| Phase II conjugation | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6647). | |||
| REF 2 | Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 5 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 6 | Entacapone: a catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson's disease. Clin Ther. 2001 Jun;23(6):802-32; discussion 771. | |||
| REF 7 | Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22. | |||
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