Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0J0ZK
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| Former ID |
DIB020325
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| Drug Name |
MEL57A
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| Synonyms |
CHEMBL1253475; MEL57A; GTPL6260; SCHEMBL16410080; BDBM50326990; 3-[(Z)-4-[[(Z)-4-(7, 8-dimethoxy-2-oxo-1H-3-benzazepin-3-yl)but-2-enyl]-[(2R)-2-(3, 4-dimethoxyphenyl)propyl]amino]but-2-enyl]-7, 8-dimethoxy-1H-3-benzazepin-2-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C43H51N3O8
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| Canonical SMILES |
CC(CN(CC=CCN1C=CC2=CC(=C(C=C2CC1=O)OC)OC)CC=CCN3C=CC4=CC(=C(C=C4CC3=O)OC)OC)C5=CC(=C(C=C5)OC)OC
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| InChI |
1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m0/s1
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| InChIKey |
WCJGGTAAPIAIJS-PSEQGZRXSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hyperpolarization cyclic nucleotide-gated channel 1 (HCN1) | Target Info | Blocker (channel blocker) | [2] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6260). | |||
| REF 2 | Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue. Br J Pharmacol. 2012 May;166(2):602-16. | |||
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