Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I8RR
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| Former ID |
DAP000984
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| Drug Name |
Streptozocin
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| Synonyms |
Estreptozocina; STREPTOZOTOCIN; STRZ; Streptozocine; Streptozocinium; Streptozocinum; Streptozosin; Zanosar; Alkylating agent; Binds to DNA; Streptozocinium [Latin]; Streptozocine [INN-French]; Streptozocinum [INN-Latin]; Zanosar (TN); Streptozocin (USAN/INN); Streptozocin, Zanosar, STZ,Streptozotocin;N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff; N-D-Glucosyl-(2)-N'-nitrosomethylurea; D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-(9CI); 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea; 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Deoxy-2[[(methylnitrosoamino)-carbonyl]amino]-D-glucopyranose; 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose
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| Drug Type |
Small molecular drug
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| Indication | Pancreatic cancer [ICD-11: 2C10; ICD-9: 157.4] | Approved | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Pfizer Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C8H15N3O7
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| Canonical SMILES |
CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
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| InChI |
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
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| InChIKey |
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
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| CAS Number |
CAS 18883-66-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9521, 596509, 7980678, 8149530, 8170920, 11335706, 11360945, 11363854, 11366416, 11368978, 11372053, 11374906, 11377140, 11461917, 11483979, 11487878, 11490902, 11493058, 11494774, 11534179, 12173581, 24899428, 26611922, 26679870, 34671698, 46508872, 47207590, 47515288, 47588962, 47662248, 47736441, 47959704, 48110424, 48184964, 48334456, 48414469, 48416558, 49699154, 50123151, 50123152, 53789885, 56311248, 56311776, 56314572, 57288842, 57310788, 57654595, 79254669, 92124251, 92307679
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| ChEBI ID |
CHEBI:9288
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| ADReCS Drug ID | BADD_D02073 | |||
| SuperDrug ATC ID |
L01AD04
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| SuperDrug CAS ID |
cas=018883664
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Streptozotocin (adjusted p-values: 5.41E-06). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Streptozotocin (adjusted p-values: 5.96E-06). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Streptozotocin (adjusted p-values: 2.59E-05). | |||
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Studied Microbe: Bacteroides ovatus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Streptozotocin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Streptozotocin (adjusted p-values: 4.08E-04). | |||
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Studied Microbe: Bacteroides uniformis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Streptozotocin (adjusted p-values: 1.32E-06). | |||
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Studied Microbe: Bacteroides vulgatus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Streptozotocin (adjusted p-values: 2.38E-06). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Streptozotocin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides distasonis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Streptozotocin (adjusted p-values: 1.62E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Streptozotocin (adjusted p-values: 1.49E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli ED1a
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli ED1a was decreased by Streptozotocin (adjusted p-values: 5.26E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Streptozotocin (adjusted p-values: 4.86E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Clostridioides difficile
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Streptozotocin (adjusted p-values: 3.28E-04). | |||
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Studied Microbe: Clostridium perfringens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Streptozotocin (adjusted p-values: 1.21E-06). | |||
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Studied Microbe: Coprococcus comes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Streptozotocin (adjusted p-values: 6.74E-06). | |||
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Studied Microbe: Enterocloster bolteae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Streptozotocin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Eubacterium eligens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Streptozotocin (adjusted p-values: 7.04E-06). | |||
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Studied Microbe: Lacrimispora saccharolytica
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Streptozotocin (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Roseburia hominis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Streptozotocin (adjusted p-values: 1.88E-05). | |||
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Studied Microbe: Roseburia intestinalis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Streptozotocin (adjusted p-values: 1.76E-04). | |||
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Studied Microbe: Ruminococcus gnavus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Streptozotocin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Ruminococcus torques
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Streptozotocin (adjusted p-values: 1.46E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Verrucomicrobiaceae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Verrucomicrobiaceae was decreased by Streptozotocin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: Bacteroidetes
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Bacteroidetes was decreased by Streptozotocin. | |||
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Studied Microbe: Deferribacteres
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Deferribacteres was increased by Streptozotocin (p < 0.05). | |||
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Studied Microbe: Firmicutes
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Firmicutes was increased by Streptozotocin (p < 0.05). | |||
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Studied Microbe: Proteobacteria
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Proteobacteria was increased by Streptozotocin (p < 0.05). | |||
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Studied Microbe: Verrucomicrobia
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | Type 2 diabetes mellitus | |||
| Description | The abundance of Verrucomicrobia was decreased by Streptozotocin. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Breaker | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | JinQi Jiangtang Tablet Regulates Gut Microbiota and Improve Insulin Sensitivity in Type 2 Diabetes Mice. J Diabetes Res. 2019 Jan 10;2019:1872134. | |||
| REF 4 | Hydrodynamics-based transfection of pancreatic duodenal homeobox 1 DNA improves hyperglycemia and is associated with limited complications in diabe... Endocr J. 2009;56(6):783-90. | |||
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