Drug Information
Drug General Information | Top | |||
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Drug ID |
D0I5WB
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Drug Name |
Clomiphene Citrate
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Synonyms |
Clomid; Milophene; Serophene
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Drug Type |
Small molecular drug
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Indication | Female infertility [ICD-11: GA31.Z] | Approved | [1] | |
Company |
Sanofi Aventis Us Llc
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Structure |
Download2D MOL
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Formula |
C32H36ClNO8
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Canonical SMILES |
CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
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InChI |
1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
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InChIKey |
PYTMYKVIJXPNBD-OQKDUQJOSA-N
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CAS Number |
CAS 7619-53-6
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PubChem Compound ID | ||||
ADReCS Drug ID | BADD_D00498 |
Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Bacteroides fragilis enterotoxigenic
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Clomiphene citrate (adjusted p-values: 8.88E-03). | |||
Studied Microbe: Bacteroides thetaiotaomicron
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides thetaiotaomicron was decreased by Clomiphene citrate (adjusted p-values: 8.33E-03). | |||
Studied Microbe: Parabacteroides distasonis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Parabacteroides distasonis was decreased by Clomiphene citrate (adjusted p-values: 8.76E-03). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
Studied Microbe: Collinsella aerofaciens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Collinsella aerofaciens was decreased by Clomiphene citrate (adjusted p-values: 2.32E-03). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia obeum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Blautia obeum was decreased by Clomiphene citrate (adjusted p-values: 3.45E-03). | |||
Studied Microbe: Coprococcus comes
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Coprococcus comes was decreased by Clomiphene citrate (adjusted p-values: 3.49E-03). | |||
Studied Microbe: Eubacterium eligens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium eligens was decreased by Clomiphene citrate (adjusted p-values: 4.10E-04). | |||
Studied Microbe: Eubacterium rectale
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium rectale was decreased by Clomiphene citrate (adjusted p-values: 1.93E-03). | |||
Studied Microbe: Roseburia hominis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia hominis was decreased by Clomiphene citrate (adjusted p-values: 2.82E-04). | |||
Studied Microbe: Roseburia intestinalis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia intestinalis was decreased by Clomiphene citrate (adjusted p-values: 2.37E-04). | |||
Studied Microbe: Ruminococcus gnavus
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus gnavus was decreased by Clomiphene citrate (adjusted p-values: 1.34E-04). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
Studied Microbe: Streptococcus salivarius
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Streptococcus salivarius was decreased by Clomiphene citrate (adjusted p-values: 9.11E-03). |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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