Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I5OR
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| Former ID |
DIB001633
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| Drug Name |
Tetrahydrouridine
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| Synonyms |
3,4,5,6-Tetrahydrouridine; NSC-112907; NSC 112907; CHEMBL2311128; 18771-50-1; U 23284; NSC-112907-D; BRN 0752319; 2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-; NSC112907; AC1L1H1G; SCHEMBL587704; 3,4,5, 6-Tetrahydrouridine; 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-.beta.-D-ribofuranosyl-; UCKYOOZPSJFJIZ-XVKVHKPRSA-N; MolPort-044-561-340; BDBM50421666; AKOS032953792; DB12484; LS-7719; CS-7633; HY-15345; 3,4,5,6-Tetrahydrouridine (> 80% by HPLC); J-012078
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [1] | |
| Company |
BioVision
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H16N2O6
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| Canonical SMILES |
C1CN(C(=O)NC1O)C2C(C(C(O2)CO)O)O
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| InChI |
1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
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| InChIKey |
UCKYOOZPSJFJIZ-XVKVHKPRSA-N
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| CAS Number |
CAS 18771-50-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cytidine deaminase (CDA) | Target Info | Modulator | [1], [2] |
| BioCyc | Pyrimidine ribonucleosides degradation | |||
| Pyrimidine ribonucleosides degradation | ||||
| Pyrimidine deoxyribonucleosides degradation | ||||
| Superpathway of pyrimidine deoxyribonucleoside salvage | ||||
| Pyrimidine ribonucleosides salvage I | ||||
| Pyrimidine deoxyribonucleosides salvage | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Panther Pathway | Pyrimidine Metabolism | |||
| Salvage pyrimidine deoxyribonucleotides | ||||
| Salvage pyrimidine ribonucleotides | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(13):1991-7. | |||
| REF 2 | Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424. | |||
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