Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I4YK
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| Former ID |
DNC000932
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| Drug Name |
Methanandamide
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| Synonyms |
methanandamide; (R)-methanandamide; R(+)-Methanandamide; AM-356; (R)-(+)-Methanandamide; CHEMBL120526; 157182-49-5; N-(1R-methyl-2-hydroxy-ethyl) arachidonoyl amine; N-(1R-methyl-2-hydroxy-ethyl)-5Z,8Z,11Z,14Z-eicosatetraenoyl amine; (5Z,8Z,11Z,14Z)-N-[(2R)-1-hydroxypropan-2-yl]icosa-5,8,11,14-tetraenamide; (R)-N-(2-Hydroxy-1-methylethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide; R-1 Methanandamide; R-(+)-methanandamide; BSPBio_001285; SCHEMBL338871; AC1O424C; GTPL2506; BML2-C03; BCBcMAP01_000201; MolPort-003-958-659
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C23H39NO2
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| Canonical SMILES |
CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC(C)CO
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| InChI |
1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(26)24-22(2)21-25/h7-8,10-11,13-14,16-17,22,25H,3-6,9,12,15,18-21H2,1-2H3,(H,24,26)/b8-7-,11-10-,14-13-,17-16-/t22-/m1/s1
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| InChIKey |
SQKRUBZPTNJQEM-FQPARAGTSA-N
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| CAS Number |
CAS 157182-49-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7850560, 7979921, 11598741, 14803494, 24896698, 26754852, 26754853, 26754854, 42971261, 47290862, 47588722, 47885128, 50110804, 53801074, 57309611, 57365602, 72404826, 76249586, 85788014, 91721439, 92309701, 99300615, 99302133, 103348814, 103951081, 104046468, 114478911, 134340217, 137249377, 139263848, 142712356, 162226840, 179205485, 226674439, 241182147, 241375230, 249966148, 252156089, 252455425, 252457535, 252463350
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [2] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | ||||
| Panther Pathway | Endogenous cannabinoid signaling | |||
| Pathway Interaction Database | N-cadherin signaling events | |||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| BDNF signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2506). | |||
| REF 2 | Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB1-dopamine D2 receptor mechanism. Brain Res. 2009 Mar 13;1260:7-14. | |||
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