Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I3PG
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| Former ID |
DIB005978
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| Drug Name |
SDZ-CPI-975
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| Synonyms |
CPT inhibitors, Sandoz; Carnitine palmitoyl transferase I inhbitors, Sandoz; SDZ-267-894
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| Drug Type |
Small molecular drug
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Discontinued in Phase 1 | [1] | |
| Company |
Sandoz Research Institute
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H44NO6P
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| Canonical SMILES |
CCCCCCCCCCCCCCOP(=O)([O-])OC(CC(=O)O)C[N+](C)(C)C
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| InChI |
1S/C21H44NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-27-29(25,26)28-20(18-21(23)24)19-22(2,3)4/h20H,5-19H2,1-4H3,(H-,23,24,25,26)/t20-/m1/s1
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| InChIKey |
HSNUXANXVHLGQT-HXUWFJFHSA-N
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| CAS Number |
CAS 157244-53-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carnitine O-palmitoyltransferase I (CPT1B) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Fatty acid degradation | |||
| Fatty acid metabolism | ||||
| PPAR signaling pathway | ||||
| AMPK signaling pathway | ||||
| Adipocytokine signaling pathway | ||||
| Glucagon signaling pathway | ||||
| Pathwhiz Pathway | Fatty acid Metabolism | |||
| Reactome | RORA activates gene expression | |||
| PPARA activates gene expression | ||||
| Import of palmitoyl-CoA into the mitochondrial matrix | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Mitochondrial LC-Fatty Acid Beta-Oxidation | ||||
| Nuclear Receptors Meta-Pathway | ||||
| PPAR Alpha Pathway | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Circadian Clock | ||||
| Fatty Acid Beta Oxidation | ||||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005522) | |||
| REF 2 | Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys. Am J Physiol. 1998 Feb;274(2 Pt 2):R524-8. | |||
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