Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I3BB
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| Former ID |
DIB014371
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| Drug Name |
KW-7158
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| Synonyms |
Non-cholinergic tricyclic (irritable bowel syndrome), Kyowa Hakko Kirin
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| Drug Type |
Small molecular drug
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| Indication | Urinary incontinence [ICD-11: MF50.2; ICD-9: 788.3] | Discontinued in Phase 2 | [1] | |
| Company |
Kyowa Hakko
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| Structure |
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Download2D MOL |
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| Formula |
C16H12F3NO5S2
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| Canonical SMILES |
CC(C(=O)NC1=C2C(=CC=C1)S(=O)(=O)CC3=C(C2=O)SC=C3)(C(F)(F)F)O
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| InChI |
1S/C16H12F3NO5S2/c1-15(23,16(17,18)19)14(22)20-9-3-2-4-10-11(9)12(21)13-8(5-6-26-13)7-27(10,24)25/h2-6,23H,7H2,1H3,(H,20,22)/t15-/m0/s1
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| InChIKey |
NAFSYPCVPLWHFY-HNNXBMFYSA-N
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| CAS Number |
CAS 214764-26-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Potassium channel unspecific (KC) | Target Info | Agonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013319) | |||
| REF 2 | KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] enhances A-type K+... J Pharmacol Exp Ther. 2004 Jul;310(1):159-68. | |||
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