Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0HK3N
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| Former ID |
DIB009085
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| Drug Name |
Belnacasan
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| Synonyms |
Second generation ICE inhibitors, Vertex; VRT-043198; VRT-43198; VX-765; VX-765)
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| Drug Type |
Small molecular drug
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| Indication | Epilepsy [ICD-11: 8A60-8A68] | Phase 2 | [1] | |
| Company |
MedKoo Biosciences; vertex pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C24H33ClN4O6
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| Canonical SMILES |
CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
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| InChI |
1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1
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| InChIKey |
SJDDOCKBXFJEJB-MOKWFATOSA-N
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| CAS Number |
CAS 273404-37-8
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46. | |||
| REF 2 | (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydr... J Pharmacol Exp Ther. 2007 May;321(2):509-16. | |||
| REF 3 | IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol. 2005 Aug 15;175(4):2630-4. | |||
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