Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0H9WR
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| Former ID |
DIB014006
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| Drug Name |
LX-1031
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| Synonyms |
LG-103; LP-389924; LP-507518; LP-533401; LP-615819; TPH inhibitor (IBS), Lexicon; Tryptophan 5-hydroxylase inhibitor(IBS), Lexicon
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| Drug Type |
Small molecular drug
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| Indication | Irritable bowel syndrome [ICD-11: DD91.0; ICD-10: K55-K64, K58; ICD-9: 564.1, 787.91] | Phase 2 | [1] | |
| Company |
Lexicon Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Formula |
C28H25F3N4O4
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| Canonical SMILES |
COC1=CC=CC(=C1)C2=CC=C(C=C2)C(C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)CC(C(=O)O)N)N
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| InChI |
1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22-,25+/m0/s1
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| InChIKey |
XNMUICFMGGQSMZ-WIOPSUGQSA-N
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| CAS Number |
CAS 945976-76-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tryptophan 5-hydroxylase (TPH) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00813098) Study of LX1031 in Subjects With Non-Constipating Irritable Bowel Syndrome. U.S. National Institutes of Health. | |||
| REF 2 | LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8. | |||
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