Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0H9FR
|
|||
Drug Name |
PRN1371
|
|||
Synonyms |
PUIXMSRTTHLNKI-UHFFFAOYSA-N; 1802929-43-6; PRN-1371; UNII-S3OPE9IA3Q; S3OPE9IA3Q; 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one; GTPL9788; US9567334, Example 6; SCHEMBL16993012; BDBM286984; BCP20493; s8578; AKOS032954157; CS-7485; compound 34 [PMID: 28665128]; HY-101768; J3.662.238E; 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one
Click to Show/Hide
|
|||
Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
Company |
Principia Biopharma South San Francisco, CA
|
|||
Structure |
Download2D MOL |
|||
Formula |
C26H30Cl2N6O4
|
|||
Canonical SMILES |
CNC1=NC=C2C=C(C(=O)N(C2=N1)CCCN3CCN(CC3)C(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl
|
|||
InChI |
1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
|
|||
InChIKey |
PUIXMSRTTHLNKI-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 1802929-43-6
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Fibroblast growth factor receptor (FGFR) | Target Info | Inhibitor | [1] |
References | Top | |||
---|---|---|---|---|
REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.