Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H2MO
|
|||
| Former ID |
DNAP001385
|
|||
| Drug Name |
Colforsin daropate hci
|
|||
| Synonyms |
Adehl (TN); Adele (TN)
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Approved | [1] | |
| Company |
Nippon Kayaku
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C27H44ClNO8
|
|||
| Canonical SMILES |
CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C.Cl
|
|||
| InChI |
1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
|
|||
| InChIKey |
VIRRLEDAYYYTOD-YHEOSNBFSA-N
|
|||
| CAS Number |
CAS 138605-00-2
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:31429
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathelicidin antimicrobial peptide (CAMP) | Target Info | Modulator | [2], [3] |
| KEGG Pathway | Salivary secretion | |||
| Tuberculosis | ||||
| Reactome | ROS production in response to bacteria | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Latent infection of Homo sapiens with Mycobacterium tuberculosis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| SREBP signalling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine. Circ J. 2002 Dec;66(12):1150-4. | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep. 2005 Apr;22(2):162-95. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.